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FlowProof

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FlowProof is the execution and provenance layer for MCP-enabled bioinformatics. Where data-access servers (e.g. GEOmcp, STRINGmcp) let an assistant look things up, FlowProof lets it actually run a pipeline and prove the result. Each run emits a Workflow Run RO-Crate recording the pipeline, exact tool versions, parameters, and SHA-256 checksums of every input and output, so an AI-produced result is reproducible byte-for-byte. It runs locally over stdio (your data stays on your machine) or as a hosted HTTP endpoint, and exposes six MCP tools: list, describe, run, status, results, provenance. Seed pipelines: ont-read-stats (Oxford Nanopore read QC, runs on a built-in sample with no input), variant-call-short, rnaseq, fetchngs, viralrecon. Install with: uvx flowproof-mcp

By ajibadehammed@gmail.com
Bioinformatics
Updated August 21, 2026
45 views

Configuration

mcpServers:
{
  "flowproof": {
    "command": "uvx",
    "args": [
      "flowproof-mcp"
    ]
  }
}

Installation

FlowProof runs locally (your data stays on your machine) or as a hosted endpoint. **Local (recommended for real data)** — requires [Nextflow](https://www.nextflow.io/) installed for real pipeline runs:
uvx flowproof-mcp
Add to your MCP client config (Claude Desktop / Cursor):
{
  "mcpServers": {
    "flowproof": {
      "command": "uvx",
      "args": ["flowproof-mcp"]
    }
  }
}
Then ask your assistant, e.g. *"list the FlowProof pipelines"* or *"run ont-read-stats"* (runs on a built-in sample with no input). **Hosted (no install):** ```json { "mcpServers": { "flowproof": { "url": "https://flowproof.specvista.com/mcp/" } } }

Tags

bioinformaticsnextflowprovenancereproducibilityro-crateworkflowspipelinesgenomicsnanoporerna-seqvariant-calling

Compatibility

claude
claude
gpt-4
gemini
other

Details

Category: Bioinformatics
Status: active
Created: August 18, 2026
Last Updated: August 21, 2026
Views: 45